Effects of red blood cell (RBC) transfusion on sickle cell disease recipient plasma and RBC metabolism
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چکیده
منابع مشابه
Practice and costs of red blood cell (RBC) transfusion in an oncological unit.
BACKGROUND Cancer related anemia impairs patient functioning. Red blood cell (RBC) transfusion and erythropoietin (EPO) may relieve fatigue. Cost-effectiveness data have been requested. PATIENTS AND METHODS All transfusions administered at the Department of Oncology, University Hospital of North Norway (UNN) in 2005 were analysed, with a total of 118 patients entering the study. A cost of tra...
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BACKGROUND Almost 2 percent of murine blood red blood cells (RBCs) are destroyed each day and are replaced by fresh RBCs generated through the process of erythropoiesis. RBCs to be destroyed are phagocytosed by macrophages in the reticuloendothelial system, especially in the spleen. CD47 molecules on RBCs may regulate the susceptibility of RBC to destruction by phagocytosis because its recognit...
متن کاملManagement of RBC-transfusion dependence.
Strategies for the management of anemia in patients with myelodysplastic syndrome (MDS) have evolved following the U.S. Food and Drug Administration (FDA) approval of three new therapeutics from one of symptom amelioration with red blood cell (RBC) transfusions to one of active treatment. Most patients develop transfusion-dependent anemia over the course of their disease, however, and its adver...
متن کاملAdherence in a randomised controlled trial comparing liberal and restrictive red blood cell (RBC) transfusion protocols after cardiac surgery (TITRe2)
Objectives The TITRe2 trial is comparing two haemoglobin (Hb) thresholds for RBC transfusion after cardiac surgery, Hb<9.0g/dl (liberal) vs. Hb<7.5g/dl (restrictive). Based on historic data, and with complete adherence, transfusion rates should be 100% in the liberal and 30% in the restrictive group. Convergence of these rates due to non-adherence severely threatens the power of the trial; ther...
متن کاملRed blood cell alloimmunization in sickle cell disease: pathophysiology, risk factors, and transfusion management.
Red blood cell transfusions have reduced morbidity and mortality for patients with sickle cell disease. Transfusions can lead to erythrocyte alloimmunization, however, with serious complications for the patient including life-threatening delayed hemolytic transfusion reactions and difficulty in finding compatible units, which can cause transfusion delays. In this review, we discuss the risk fac...
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ژورنال
عنوان ژورنال: Transfusion
سال: 2018
ISSN: 0041-1132
DOI: 10.1111/trf.14931